#96 - Interview with John Klepper - Serial Entrepreneur, Board Member, Strategist, Innovator, Speaker and founder

00:00:06: Capricorn Connect.

00:00:08: People.

00:00:09: Potential.

00:00:10: Technology.

00:00:15: The serial entrepreneur, board member,

00:00:19: strategist, innovator, speaker and founder and CEO of PIPRA.

00:00:24: With PIPRA, John Klepper

00:00:26: developed a groundbreaking

00:00:28: AI based technology which prevents

00:00:31: the outbreak of the disease delirium.

00:00:33: Today we'll talk about what this

00:00:35: disease is delirium.

00:00:37: and how to prevent it, but also what motivated John in developing

00:00:42: this groundbreaking technology.

00:00:44: John, thank you so much for being here in the podcast.

00:00:46: Now also as a video podcast,

00:00:50: how are you today?

00:00:51: Thanks, Jacob.

00:00:51: It's a pleasure to be here.

00:00:52: I'm doing great.

00:00:55: Love what you've set up here, too.

00:00:57: It's really spectacular.

00:00:59: John, tell us and the audience about Pipra.

00:01:03: What is the background of the company and what motivated you setting this technology up?

00:01:10: With pleasure.

00:01:11: So I've always been very motivated by impact, wanting to try to do good and give back.

00:01:19: I was working in Alzheimer's disease, early detection and prevention.

00:01:23: and for the same reasons, and then I came across this disease area called delirium, which I discovered is massively underserved and underrepresented, has awful consequences for the patients, for relatives, and also is a massive cost to hospitals, so I got super excited about trying to solve this problem, and then put an amazing team together.

00:01:54: to help us do that.

00:01:56: You also had

00:01:56: a personal motivation behind it.

00:01:58: Yeah, so there was a combination of this massive opportunity from a business perspective, from an emotional perspective, to be able to do good.

00:02:10: But as I learned more about Delirium, and I'm happy to talk a little bit more about what that is, I called my mother up and I asked her if she could tell me in a bit more detail what what had happened to her in hospital some years back.

00:02:28: And she described this terrifying experience where she woke up after surgery and she was in her room and she thought that there were monsters coming out of the walls.

00:02:40: She thought the staff were trying to kill her.

00:02:43: She was for several days, she was terrified and most patients that have delirium will describe it as the most terrifying experience of their life.

00:02:51: So it's like hallucination?

00:02:54: Hallucination, memory loss, confusion, disorientation.

00:03:01: For many patients they recover within some days or weeks.

00:03:07: My mother luckily had a full recovery.

00:03:11: But many patients don't and they end up.

00:03:13: instead of going back home after the hospital They go to a nursing home.

00:03:17: They have dementia or they die within a month.

00:03:21: and What is very sad is that this disease is very preventable And there's just not enough awareness about it within hospital.

00:03:34: There's not enough awareness about it.

00:03:36: this disease in the general public.

00:03:38: there's not enough people asking questions about, you know, is this going to happen?

00:03:42: So what very often happens is people will say, especially when I do public speaking and talks, when I'll always have a few people afterwards come up to me after this talk and say, thank you so much for sharing your story, you know, this happened to my mother or to my father, my grandfather, you know, like they went to the hospital, they were super sharp, they had a hip surgery or knee surgery or whatever it is, you know, and they were never the same afterwards.

00:04:08: And what they're describing is delirium.

00:04:11: And so yeah, so we're together with my team.

00:04:14: We've been able to develop AI-based algorithms to help predict which patients are at risk and then to help support the prevention of delirium within hospital.

00:04:28: And how much, if we talk numbers, how much do you think you can prevent with PIPRA?

00:04:34: the outbreak of delirium, like if you percentage wise,

00:04:39: have

00:04:39: any estimates?

00:04:40: Yeah, no, not estimates.

00:04:41: We actually have.

00:04:43: we have proof now.

00:04:45: We did one of one of the hospitals we work with here in Switzerland, one of the major hospitals, private hospital, we.

00:04:53: they did a publication on the use of PIPRA in their hospital, showing a twenty nine percent reduction of incidents in in in their hospital.

00:05:02: And then since then, we've implemented in several other hospitals, including in Spain and Germany.

00:05:09: In one of the major hospitals in Madrid in Spain, Getafe Hospital, we show a forty-three percent reduction in incidents.

00:05:17: Wow.

00:05:18: And in Munich and LMU, we show a seventy-two percent reduction of delirium.

00:05:24: Wow.

00:05:24: Impressive.

00:05:24: Within their hospital.

00:05:26: So... We have now proven that we can not only predict which patients are at risk, but we can actually reduce this incidence massively, which is, of course, amazing for the patients, for the relatives, but also massively cost-effective.

00:05:43: It saves millions for the hospital because delirium is actually one of the most expensive problems in healthcare, and I can give you some figures around that.

00:05:54: It's sixty percent more expensive to healthcare than diabetes.

00:05:58: Wow.

00:05:58: So you also would help the system with this technology.

00:06:02: So it's not just like the patients, but also the system itself.

00:06:06: Yeah.

00:06:06: So what happens when a patient has delirium?

00:06:10: They end up staying much longer in hospital.

00:06:13: They end up needing much more care while they're in hospital.

00:06:16: It's often extremely stressful for the staff.

00:06:20: And because they're staying much longer in hospital and have all these complications, It often leads to other complications like an increase in falls, infections, pressure ulcers, readmission rates go up massively.

00:06:38: So all of these come at a cost.

00:06:40: So it's like a chain reaction.

00:06:41: Exactly.

00:06:42: So by reducing delirium, which is by far the most prevalent in hospital acquired complication.

00:06:49: And again, I'll give you some numbers on that.

00:06:51: It's twenty-three percent of patients over the age of sixty.

00:06:54: So nearly one in four patients over sixty.

00:06:57: Going to the hospital will have delirium.

00:07:02: So you reduce to delirium.

00:07:03: you're also reducing all these other complications which hospitals are spending millions trying to avoid infections.

00:07:11: They go out of their way and spend a lot of time and effort and money to try to reduce infections or falls.

00:07:17: So

00:07:17: and this is another pharma product.

00:07:20: It's not a medication.

00:07:21: It's a AI based technology.

00:07:23: Can you elaborate a little bit about how?

00:07:27: you use AI for this product, so I get a better picture.

00:07:32: Yeah, sure.

00:07:34: So it is non-pharmacological in its approach.

00:07:39: There is no magic pill today.

00:07:43: So there is no treatment.

00:07:45: If you get delirium, you basically, most you can do is sedate the patient, and that's often worse for the patient, but makes it a bit easier for the staff.

00:07:56: So what... What we do is we know the risk factors for delirium.

00:08:02: And there are many.

00:08:03: It's very multifaceted, much like dementia.

00:08:05: It's very multifaceted.

00:08:08: For one person, it might be something to do with their diet or their lack of sleep.

00:08:13: For another person, it might be polymedication.

00:08:16: There's all different kinds of things.

00:08:17: Age is obviously a big risk factor.

00:08:20: And so when a patient is admitted to the hospital, there's a lot of information that's entered into the electronic health record about the patient history.

00:08:31: What is their age?

00:08:32: What is their height and weight, BMI?

00:08:36: What's their ASA score?

00:08:37: ASA score, like how frail are they?

00:08:40: What's the risk of the surgery, for example?

00:08:42: Is it a small surgery or is it a larger, more evasive surgery?

00:08:46: All this information gets entered into the HR.

00:08:49: And our system grabs the relative and necessary information, the risk factors that are relevant, and then calculates the risk in real time, stratifies that risk into risk groups from highest risk to lowest risk, right?

00:09:04: And then communicates that to all the people in the hospital, the clinicians that need to know this highest patient.

00:09:09: And then we monitor and see, make sure that that patient gets the right treatment, make sure that the compliance is high on prevention, which is non-pharmacological.

00:09:19: and make sure that they're getting the care that they need.

00:09:24: So we're managing the pathway, the care pathway, and we're making recommendations for what to do to ensure that that patient doesn't get delirium.

00:09:33: And on top, which is really important actually, especially in prevention, it's really important to show outcomes.

00:09:42: What is the reduction in incidents?

00:09:43: What is the reduction in length of stay?

00:09:45: What is the reduction in nursing hours?

00:09:46: Why?

00:09:48: Because Unlike most medicine, which is reactive, you see a patient is bleeding, you stop the bleeding, you know that the work you did had a result.

00:10:03: In the case of prevention, the patient is fine, and then you do this prevention work, and they're still fine.

00:10:13: They didn't get delirium.

00:10:14: But how do you know that what you did wasn't just wasting time?

00:10:24: effort to put out work preventively rather than reactively.

00:10:30: You need to show the outcomes.

00:10:31: You need to show that what they're doing is actually having an effect.

00:10:36: And most healthcare professionals, they will be willing to do a little bit of extra work if they know that what they're doing is actually having a result, right?

00:10:45: Absolutely.

00:10:46: And in the balance, actually, because we're reducing the incidence so much, we're actually saving them a lot of time because patients need much less care.

00:10:53: Delirium patients need a lot of care, so

00:10:55: that's so AI a huge help here in this context.

00:11:01: So AI helps saving lives.

00:11:03: essentially hundred percent hundred percent.

00:11:06: John I also have some questions.

00:11:09: I'm quite interested in your background.

00:11:11: You have a very interesting background.

00:11:13: I mean you used to work in the film industry.

00:11:15: What brought you from the film industry into the yeah health care sector.

00:11:20: Maybe you can tell our viewers also a little bit about that.

00:11:23: Sure.

00:11:24: Definitely wasn't planned.

00:11:32: I think we've talked about this before.

00:11:36: As an entrepreneur, your mindset is you're always looking at opportunities to change something, to make a difference, to innovate.

00:11:48: You're always looking at life through a lens of how could this be better?

00:11:51: Or why isn't somebody doing this thing?

00:11:55: And with that lens, perhaps, when I was, so I started off in the, in art, I was a trained artist, traditionally trained, painting sculpture, and then I went into photography, and then I got excited about film, and while I was doing my masters at the American Film Institute in Los Angeles, one of my teachers said, hey, I'm starting up a production company in visual effects.

00:12:29: Do you want to help me get it off the ground?

00:12:31: And I was like, that sounds great.

00:12:36: As soon as I finished my masters and he's like, no, no, we're going now.

00:12:40: So I had to kind of figure out how to do both.

00:12:42: So there's a lot of nights and weekends.

00:12:44: And then we built this production company, which grew very quickly.

00:12:50: And we ended up working on some pretty exciting big feature films like the Matrix movies.

00:12:59: And I got to taste what it feels like to be an entrepreneur.

00:13:05: And then from there, I moved back to Europe and I started a similar animation visual effects company in Sweden.

00:13:18: Brought an international team from all over the world to work on some pretty exciting things.

00:13:26: and then built that company up to at one point we had about seventy people in three countries and then exited from there and started a software company.

00:13:41: that was a social enterprise which basically supports about forty different non-profit and charity organizations around the world.

00:13:49: through this gamified giving which is still running.

00:13:54: So I was able to do a lot of good in the world, which I'm very proud of and my team is very proud of.

00:14:01: And then I had a coffee with a neuroscientist and we got into it and I'm fascinated by brain health and always have been.

00:14:16: So I started challenging him on some of the ideas he had for a business and throwing some ideas out.

00:14:27: a few hours into this conversation, he asked me if I wanted to start a company with him.

00:14:34: Uh, and I love challenges.

00:14:39: So, I mean, at first I asked him, I said, look, I'm not a doctor.

00:14:42: I'm not a scientist.

00:14:43: Why would you want to, why would you want to work with me?

00:14:46: He said, well, I've got that part covered.

00:14:49: I need a business guy who understands how to run a company.

00:14:52: And then it started to click that no matter what field you're in, running a business is fairly similar.

00:14:57: Like there's, you know, You need to put a brilliant team together.

00:15:01: You need to make sure they're all motivated and working and running in the same direction.

00:15:04: You need to make sure that they're all paid.

00:15:06: You need to make sure that you're balancing finances, that you have a strong strategy and you have a sales team and you have all of the different things that you need to run a company.

00:15:17: It's all basically the same thing, right?

00:15:19: You need to manage the board, you need to report, you need to have good governance.

00:15:23: All these things are pretty much all the same.

00:15:27: So yeah, so it's exciting because I get to learn new things all the time in each industry and I get to work with brilliant people.

00:15:36: And we do have an incredible team at Beeprov.

00:15:38: There's some fantastic PhDs and doctors and scientists and AI experts.

00:15:47: And with all your experiences in scaling companies, setting up company structures, organizations, what do you think

00:15:55: are

00:15:56: sort of the challenges that you always have when the company starts

00:16:01: to grow?

00:16:05: Yeah.

00:16:08: So, you know, finding the right team is, I think, one of the biggest challenges and so, so, so important.

00:16:20: It's so much more important to hire somebody that you know is going to work well in your team culturally and has the passion and the motivation really has the drive, especially at a startup because there's so many ups and downs and there's so many times where you need to pull together and you need to support each other and you need to go through difficult times.

00:16:43: And if the people don't have that drive and that commitment and that passion and they don't have that culture, that feeling of team, they're just gonna leave when it gets a bit difficult, right?

00:16:55: So that's, I think, one of the biggest challenges.

00:16:58: And I think what that looks like in reality is You know, you see an amazing CV and you think, oh, this would be perfect.

00:17:05: We need this person so desperately.

00:17:07: But you have this feeling that culturally, they might be complicated.

00:17:12: It might be difficult.

00:17:13: It might not fit in quite right.

00:17:16: Do not hire that person.

00:17:18: Like trust your gut.

00:17:19: So culture is important.

00:17:20: Culture and the gut feeling.

00:17:22: The gut feeling.

00:17:23: Yeah.

00:17:24: Like, you know, it's, it's.

00:17:26: It's a relationship, just like a normal relationship.

00:17:31: You're working with this person all the time, and they're working with the team.

00:17:36: And everybody needs to have that, I mean, of course, you fight, you have, it's very healthy, but at the end of the day, you need to get along.

00:17:45: You need to have that drive and that passion.

00:17:49: Would

00:17:49: you rule somebody out who has sort of the perfect CV and comes from big corporate?

00:17:55: or really, a

00:17:56: hundred percent.

00:17:57: Yeah, and I've made that mistake before.

00:18:00: You know, a couple times, hiring the perfect CV, because I really needed that position filled, you know, and it had been three, four, five months, I hadn't found somebody, you know, and here comes this perfect CV.

00:18:10: Had a bad feeling, or not a bad feeling, but something didn't feel quite right, you know.

00:18:17: Yeah, big mistake.

00:18:19: In one case, it almost cost me the company.

00:18:22: Oh, wow.

00:18:23: Yeah.

00:18:25: So it's so important.

00:18:28: But then other challenges, raising capital is a really huge, huge challenge.

00:18:39: It's unbelievably time consuming.

00:18:43: To do it well, it's a full time job.

00:18:47: If you're lucky, you can get it done in a short window, maybe three, four months, five months.

00:18:51: But especially in today's climate, Investors are much more risk averse, and they're much more cautious.

00:19:02: They're expectations for what they want to see at pre-seed, at seed, at series A is much higher than it used to be.

00:19:10: So timelines stretch, and you need to be able to manage your business, run the business, while also raising capital.

00:19:20: And you have to have a lot of grit because... that's a lot of nose and it's a lot of patience and it's scary during that time.

00:19:31: Because one of your number one responsibilities as a founder or CEO is to make sure the company has cash.

00:19:38: And if you're a company that, especially in deep tech, where you have a long road, especially B to B, where you have a long road before you're break even or profitable, raising capital is... Live or die.

00:19:55: So it's a tremendous amount of pressure and One of the things that I really really appreciate is spending time with fellow founders entrepreneurs And just being authentic and being honest about how difficult it is and sometimes how lonely it is and just being able to share that with other people is It's so important.

00:20:21: I think it also gets a bit glorified sometimes maybe like the whole entrepreneurship thing.

00:20:26: Yeah, maybe.

00:20:28: I mean, it definitely has its pluses.

00:20:30: You know, there's.

00:20:31: I wouldn't do it.

00:20:31: We wouldn't do it if it wasn't for, you know, if it works, it's pretty good.

00:20:35: You know, it's.

00:20:36: there's a lot of fabulous, you know, moments where you jump up and down and you hug each other and you celebrate, you know, with your team and with your fellow founders.

00:20:44: But for every one of those moments, there's ten.

00:20:48: like, oh my god, what are we gonna do?

00:20:50: And you just feel the weight on your shoulders get heavier and heavier and heavier.

00:20:56: The highs are pretty great, the lows

00:20:58: are pretty low.

00:21:01: And so, you know, I'm very fortunate at Piper that I have two amazing founders who are, you know, super supportive and... And I hope I'm the same.

00:21:15: you know for them, but we we also You know we support each other also in our private lives, you know if one of us is going through something We're there for for the other and make sure that they take time You know with with their family with their friends whatever is needed.

00:21:32: and But it's yeah, it's a journey and it is not for the thin thin skin or the thin hearted light-hearted.

00:21:41: so

00:21:41: you need a thick skin definitely

00:21:43: Yes.

00:21:44: John, what is the plan for the future for PIPRA?

00:21:49: I mean, so our vision is, for now, is a world without delirium.

00:21:56: And it may sound niche, right?

00:21:59: Because delirium, I haven't heard of delirium.

00:22:01: But as I said, it's, it's sixty percent more expensive to healthcare in the United States than diabetes.

00:22:06: Diabetes is a huge problem in the States.

00:22:10: Yeah.

00:22:11: So that gives you an idea of the costs.

00:22:12: I think it's estimated.

00:22:14: A couple years ago at a hundred and fifty six billion dollars a year to US healthcare where diabetes is around ninety billion.

00:22:24: It also affects that we know about sixty million people per year and growing Globally globally.

00:22:31: Yeah, it's it's probably a bigger number than that because there's seventy percent of cases are missed.

00:22:36: They're not diagnosed.

00:22:39: so So it is by itself a huge problem and we could continue to focus just in delirium, but At a certain point, we want to expand beyond that into other types of complications, cognitively or not.

00:22:55: So I think dementia is a very interesting area that we want to explore.

00:23:03: It's also very closely linked to delirium.

00:23:06: And I can tell you how.

00:23:09: So if a patient has delirium in hospital.

00:23:14: Their risk of having dementia Goes up a thousand four hundred percent.

00:23:20: Wow, that's crazy.

00:23:21: Yeah, so in in many ways, it's like pre-dimension And so you go in for you know like a knee surgery for example.

00:23:32: You're you're you're seventy years old and you think you know my knee hurts a little bit and I can't do the sports that I used to.

00:23:38: and You know I can still walk and I can still do some things, you know, and I can.

00:23:42: I can.

00:23:43: you know My life is not that bad, but I can't do tennis anymore.

00:23:48: I can't play tennis anymore.

00:23:49: So you so you think I'll just go have that surgery.

00:23:52: It'd be fine, right?

00:23:55: It would people be willing to take that risk if they knew they were at a reasonably high risk of having dementia of losing their memory of ending up in a nursing home or dying?

00:24:10: No Would they cancel the surgery?

00:24:14: Not necessarily most of the time they wouldn't.

00:24:17: But you could have a conversation with your doctor and you could say, could we do something minimally evasive and see how that goes?

00:24:25: Or, you know, I actually have a very high risk and I think I'll live with the need the way it is.

00:24:32: Now there are of course other emergency situations, there are life-threatening operations you have to have.

00:24:37: And in that case, if the hospital is using PIPRA, Then even if they're at high risk their chances of getting delirium are massively reduced because they're getting the right care They're getting the right attention.

00:24:51: So it's not that we're saying, you know, you're gonna cancel surgeries, but you're gonna get the right attention To make sure you don't get this.

00:24:59: Okay, so huge impact John.

00:25:02: finally I have still some personal question if it's okay with you.

00:25:06: also question I love to ask my guest is If you had a choice you can walk out of the studio today with a new superpower, which one would you

00:25:16: pick?

00:25:18: Next to your other superpowers that you

00:25:19: already have?

00:25:23: Yeah, that's a great question.

00:25:26: empathetic resonance I would say would be maybe one of them.

00:25:31: Please explain.

00:25:32: Yeah.

00:25:33: Um, so like the ability to feel and understand the emotions of others.

00:25:39: I think that's super important, especially today.

00:25:43: There's so much disconnect.

00:25:45: Right.

00:25:47: Um, people are, can't just have a conversation anymore.

00:25:52: And, uh, so I think that would be a superpower because what we say and what we feel are often very different.

00:26:02: Right.

00:26:02: And if you extend that to.

00:26:04: how that would affect your relationship, at home, with your family, how it would affect your coworkers, your team, your friends.

00:26:15: If you really knew what people were feeling, I think that's maybe one of them.

00:26:21: And I don't know, maybe temporal insight, another one, right?

00:26:26: So not being able to change the future, but... to be able to, at least from time to time, occasionally see into the future and understand.

00:26:37: if the decisions you make now, what are the implications of that decision in the future?

00:26:42: Yeah.

00:26:43: I would love to have that too.

00:26:44: Right?

00:26:45: Yeah.

00:26:45: Yeah.

00:26:46: That's a good one.

00:26:46: Or two good ones.

00:26:49: And then which autobiography would you buy if you would pick one?

00:26:57: So many good ones.

00:26:58: I haven't read Trevor Noah's Born a Crime.

00:27:02: You wrote one?

00:27:03: Yeah.

00:27:03: He's the comedian, right?

00:27:04: Yeah, exactly.

00:27:05: Also a podcaster.

00:27:08: But he had the Daily Show, I think it was the Daily Show for many years.

00:27:16: Not a podcaster, but an interviewer.

00:27:17: He did a lot of interviews in South Africa and half Swiss actually.

00:27:24: Fantastic guy and got to meet him very briefly in Doha.

00:27:31: Qatar actually because he was.

00:27:32: he was there at Web Summit and I was also doing a talk there.

00:27:37: But yeah, so I think I think that would be a fun one to read because I think he's.

00:27:44: he's brilliant.

00:27:46: he's had the chance to talk to presidents from around the world and so many amazing influential people.

00:27:56: But he's also a comedian.

00:27:58: So I've heard that it's quite funny.

00:28:00: It brings a lot of humor into it, too, which you have to bring humor into life as often as you can, I think.

00:28:08: So that would be a good one, I think.

00:28:11: And final question, John.

00:28:12: How will AI improve your life in two years?

00:28:16: How will it improve my life?

00:28:23: Because we could go the other way with that conversation, too.

00:28:25: I mean, I think, and I'm hopeful that health care is going to continue to be an area of massive disruption and innovation through the use of AI, like what we're doing at PEPRA.

00:28:53: There's really some incredible, exciting technology happening in the field of AI and drug discovery and gene editing and protein folding.

00:29:11: I mean, just the list goes on.

00:29:14: So how that affects me personally, I mean, I'm, I'm luckily, I'm still, I'm very healthy at the moment.

00:29:21: I focus a lot of time and energy on trying to maintain a healthy lifestyle.

00:29:27: I've been doing intermittent fasting for ten years.

00:29:30: Will you recommend that?

00:29:32: Oh, a hundred percent, a hundred percent.

00:29:34: Yeah, it's one of the best decisions I've ever made.

00:29:36: That's like

00:29:36: what, how many hours without eating?

00:29:38: Typically sixteen or more.

00:29:41: Yeah, like you want to try to do a minimum of sixteen.

00:29:43: So I basically don't eat breakfast.

00:29:45: And most people are like, oh, but breakfast is the most important meal of the day.

00:29:49: And I love it so much.

00:29:50: It is not the most important meal of the day.

00:29:52: That's nonsense.

00:29:52: That's Kellogg's that came up with that nonsense, right?

00:29:55: Good marketing.

00:29:56: That is a hundred percent branding, you know?

00:29:59: That's right.

00:30:00: That's right up there with, uh, you know, De Beers, you have to a diamond and it has to be three months.

00:30:06: Well, first it was one month salary.

00:30:08: And then they changed it.

00:30:09: They changed it to it has to be two months salary.

00:30:11: And I mean.

00:30:13: Like the milk thing.

00:30:14: The milk is healthy.

00:30:15: Yeah,

00:30:15: yeah, yeah.

00:30:16: Exactly.

00:30:18: So, so, I mean, you know, as hunter-gatherers, we ate for thousands of years, we ate when there was food available, right?

00:30:26: And often we didn't have food.

00:30:27: So we fasted without knowing we were like meaning to fast.

00:30:31: But that, that what happens in our bodies during the fasting is, is, is super exciting.

00:30:38: as we go through the different phases of Ketosis we start burning fat then we go into autophagy We start repairing damage and then we go into cell repair and rejuvenation usually around seventy two hours.

00:30:50: So if you do longer fast, which I do from time to time you basically start resetting your clock and you start Going into this rejuvenation process Creating new stem cells and it's so it's

00:31:02: what was your longest fasting period?

00:31:06: Seven days.

00:31:11: So and it's it.

00:31:13: you know, it seems hard, but like for example the breakfast thing, right?

00:31:15: So we have this.

00:31:18: We produce this hormone called ghrelin and That's basically our hunger hormone.

00:31:23: It tells us usually about a half an hour before we're normally eat our normal schedule that hey getting hungry time to eat.

00:31:31: So if you stop eating breakfast first few days, it's painful because your body is still producing ghrelin, but your body adapts And after a few days, you stop producing as much ghrelin and it just slowly tapers off to the point that you no longer feel hungry.

00:31:47: It's usually about seven to ten days and you just don't feel hungry anymore.

00:31:51: And it's the same thing that happens if you move to another time zone, right?

00:31:56: So if you go to the states, for example, and you're six hours or nine hours ahead or behind, you're... you're hungry at weird times for a little while and then your body just adapts.

00:32:08: You start eating in a normal schedule and you start feeling hungry at that time zone.

00:32:13: So the body adapts.

00:32:14: The body adapts.

00:32:16: So let's take it less tired like if you eat less

00:32:19: like.

00:32:21: I heard of this effect.

00:32:22: Yeah, you

00:32:22: actually end up getting more energy and what I learned is super interesting and I'm sure a lot of your viewers know this but the reason why we have so much more energy when we fast?

00:32:36: because it doesn't make sense, right?

00:32:37: You're like, you think, I don't have any food or I haven't had as much food.

00:32:40: I should have less energy.

00:32:42: But your body's number one principle is what?

00:32:47: It's survival, right?

00:32:49: We are built and engineered to survive.

00:32:53: And as we go longer and longer without food, our body goes, oh, hey, you could die.

00:33:00: Like you need to eat.

00:33:02: So you end up becoming like a superhuman.

00:33:05: So you ask me about superpowers.

00:33:07: Your body is like, you become like a superhuman.

00:33:13: So that you can go hunt.

00:33:14: And you can be a super efficient hunter.

00:33:17: And you can have super focus, right?

00:33:21: You become really focused.

00:33:23: So that you can get food, you can eat, and you can continue to live.

00:33:27: I need to try that over Christmas.

00:33:29: It's gonna be hard.

00:33:30: the fasting.

00:33:31: Oh, maybe not over Christmas, because that's a really fun time to eat, but maybe after.

00:33:38: It could be a New Year's resolution.

00:33:40: John Klepper, CEO and founder of PIPRA.

00:33:43: It was a huge pleasure.

00:33:45: Thank you so much for being here.

00:33:46: I wish you all the best.

00:33:47: Of course, Merry Christmas and also have a great two thousand twenty six and hope to see you soon.

00:33:55: Thank you so much, Jacob.

00:33:56: The same to you.

00:34:05: Capricorn connect people potential.